Trypanosoma brucei brucei

Efficacy of repeated doses of diminazene aceturate (Dinazene®) in the treatment of experimental Trypanosoma brucei infection of Albino rats

The efficacy of repeated doses of Dinazene® in Albino rats experimentally infected with Trypanosoma brucei (Gboko strain) was investigated. A total of 30 adult female Albino rats weighing 130-190 g were used for the study. They were assigned to six groups (groups A-F) of five rats each. Groups A-D were infected intraperitoneally with 1.0 × 106 trypanosomes in 400 μL of PBS diluted blood while g...

Urinary Biochemical Changes, Histopatologic Effect of Kidney Damage Observed in Rats Infected with Trypanosoma b. brucei

Several investigations have used immunological techniques in elucidating the effect of host parasite relationship in animals to understand that of man. Sleeping sickness, a tropical disease in man is caused by Trypanosoma brucei rhodesiense and Trypanosoma brucei gambiense. The related species Trypanosoma brucei brucei causes Nagana disease and rapid death in domestic animals. Trypanosomiasis c...

Increased Trypanosoma brucei cathepsin-L activity inhibits human serum-mediated trypanolysis

Most African trypanosomes, including the veterinary species Trypanosoma brucei brucei and T. congolense are susceptible to lysis by human serum. A recent study by Alsford et al. [PLoS Pathogens (2014) 10, e1004130] has identified a T. b. brucei lysosomal cathepsin with an inhibitory effect on human serum's trypanolytic action.

Wild chimpanzees are infected by Trypanosoma brucei

Although wild chimpanzees and other African great apes live in regions endemic for African sleeping sickness, very little is known about their trypanosome infections, mainly due to major difficulties in obtaining their blood samples. In present work, we established a diagnostic ITS1-based PCR assay that allows detection of the DNA of all four Trypanosoma brucei subspecies (Trypanosoma brucei br...

The power of network-based drug design and the interplay between metabolism and gene expression in Trypanosoma brucei

The power of network-based drug design and the interplay between metabolism and gene expression in Trypanosoma brucei

Multiplex analysis of RNA interference defects in Trypanosoma brucei.